Key result
Low platelet monoamine oxidase activity was associated with higher incidences of major depression and hypomania over an 18-month follow-up in college students.
Cohort
Biological markers such as platelet monoamine oxidase activity may help predict the onset of affective disorders in college students.
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May flag at-risk college students for affective disorders; hypothesis-generating and requires prospective validation before any clinical role.
A prospective investigation using platelet monoamine oxidase activity and cortical evoked response augmenting/reducing to predict the onset of new episodes of affective disorders was conducted in a college sample. During an 18-month period between clinical interviews, higher incidences of major depression and hypomania characterized the low MAO/aociated with affective psychopathology in the original retrospective study.
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Haier et al. (1980) conducted a cohort in Affective disorders. Low platelet monoamine oxidase (MAO) activity was evaluated on Onset of new episodes of affective disorders (major depression and hypomania). Low platelet monoamine oxidase activity was associated with higher incidences of major depression and hypomania over an 18-month follow-up in college students.
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