Key result
Adherence to treatment in patients with ischemic heart disease and heart failure correlated with left ventricular end-diastolic volume (r=-0.33, p<0.05) and global longitudinal strain (r=0.53).
Why the study?
Does adherence to treatment correlate with myocardial dysfunction in elderly and senile patients with ischemic heart disease and heart failure?
Observational (n=86)
Does adherence to treatment correlate with myocardial dysfunction in elderly and senile patients with ischemic heart disease and heart failure?
Effect estimate: r = -0.33 for LVEDV; r = -0.37 for E/e'; r = 0.53 for GLS
p-value: p=<0.05
Lower adherence to therapy in senile patients with ischemic heart disease and heart failure correlates with more pronounced structural and functional myocardial dysfunction.
Poor adherence was associated with worse GLS and diastolic parameters in senile IHD/CHF patients; hypothesis-generating and requires prospective trials before informing practice.
The aim of the study was to study the influence of adherence to treatment on myocardial dysfunction in elderly and senile patients with ischemic heart disease (IHD) and chronic heart failure (CHF). Material and methods. The study included 86 patients with ischemic heart disease (CHD) of older age groups admitted to hospital treatment because of the progression of CHF: 21 patients — 65 to 74 years, 65 patients — 75 to 89 years. A standard clinical study, echocardiography with global longitudinal strain assessment (GLS), and a Morisky-Green test were performed. Results . It is established that in the group of persons of senile age there is a lower adherence to treatment and more pronounced structural and functional changes in the myocardium. The following correlations were revealed: total score of the Morisky-Green test with the left ventricular end-diastolic volume (r = -0.33, p <0.05), with the E/e’ (r = -0.37, p <0.05), with GLS (r = 0.53). Conclusion. The findings indicate a lower adherence of the senile patients on treatment of IHD and CHF in comparison with the elderly. Low adherence to therapy, as well as postinfarction cardiosclerosis, can apparently be considered as one of the factors contributing to the progression of myocardial dysfunction.
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Nikishchenkova et al. (2018) conducted an observational in Ischemic heart disease and chronic heart failure (n=86). Adherence to treatment was evaluated on Correlation between Morisky-Green test score and myocardial dysfunction parameters (LVEDV, E/e', GLS) (r = -0.33 for LVEDV; r = -0.37 for E/e'; r = 0.53 for GLS, p=<0.05). Adherence to treatment in patients with ischemic heart disease and heart failure correlated with left ventricular end-diastolic volume (r=-0.33, p<0.05) and global longitudinal strain (r=0.53).
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