Key result
ACEi plus spironolactone resolves gross hematuria in a single patient with nephroptosis.
Why the study?
Does an ACE inhibitor and spironolactone improve gross hematuria in a patient with nephroptosis?
Does an ACE inhibitor and spironolactone improve gross hematuria in a patient with nephroptosis?
RAAS blockade with an ACE inhibitor and spironolactone may be effective in treating gross hematuria caused by nephroptosis.
May support RAAS blockade for hematuria in nephroptosis; leaves open generalizability beyond this single case.
Gross hematuria caused by nephroptosis is difficult to treat and sometimes requires surgical treatment. We experienced a case of a 64-year-old woman with gross hematuria due to nephroptosis and glomerular thin basement membrane that showed remission of hematuria with the blockade of the renin-angiotensin-aldosterone system with an angiotensin-converting enzyme inhibitor and spironolactone.
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Tojo et al. (2006) studied this question. An ACE inhibitor combined with spironolactone induced remission of gross hematuria caused by nephroptosis and glomerular thin basement membrane in a 64-year-old woman.
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