Key result
Remimazolam shows comparable AKI risk to sevoflurane in elderly total knee arthroplasty patients.
Why the study?
The study evaluated the incidence of postoperative acute kidney injury and complications when remimazolam or sevoflurane was used in elderly patients undergoing total knee arthroplasty.
Does remimazolam reduce the incidence of postoperative acute kidney injury compared to sevoflurane in elderly patients undergoing total knee arthroplasty?
Comparison
Remimazolam vs sevoflurane
Design
Randomized controlled trial
Follow-up
Postoperative day 2
Authors
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Comparable AKI rates with remimazolam versus sevoflurane; confirms intraoperative hemodynamic stability alone insufficient to prevent postoperative renal injury.
RCT (n=78)
Randomly allocated
Does remimazolam reduce the incidence of postoperative acute kidney injury compared to sevoflurane in elderly patients undergoing total knee arthroplasty?
In elderly patients undergoing total knee arthroplasty, remimazolam maintained higher intraoperative heart rate and blood pressure compared to sevoflurane, but did not reduce the incidence of postoperative acute kidney injury.
Lee et al. (2023) conducted an RCT in Total knee arthroplasty (n=78). Remimazolam vs. Sevoflurane was evaluated on Incidence of acute kidney injury (AKI) on postoperative day (POD) 2. Remimazolam resulted in a comparable incidence of acute kidney injury on postoperative day 2 compared to sevoflurane in elderly patients undergoing total knee arthroplasty.