Organic chemistry to the rescue: Two unrelated nonenzymatic chemical reactions can support the growth of auxotrophic E. coli strains by generating essential nutrients in situ. These biocompatible reactions, which take place in the presence of the organisms and are designed to interface with cellular metabolic processes, provide a means of linking the growth of an organism to the success of a nonbiological chemical transformation.
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Lee et al. (2013) studied this question.
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