Selected [2+2+2] cycloadditions, alkene–alkyne coupling and fusion of enyne with diazo compound, all triggered by an artificial organometallic ruthenium catalyst are demonstrated to proceed under ambient aerobic aqueous conditions in presence of bodily fluids or cell lysate. To the best of our knowledge, these are the first examples of bio- and air-tolerant C–C bond formation catalyzed by an artificial organometallic compound.
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Adriaenssens et al. (2009) studied this question.
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