Systemic and Renal Circulatory Changes Following the Administration of Adrenin, Ephedrine, and Paredrinol to Normal Man

This report concerns the systemic and renal circulatory changes in normal man during the action of adrenin, ephedrine, and paredrinol.Special attention has been paid to the interrela- tionship and integration of the many factors in- volved in the production of the over-all response.Although these three substances are similar chemi- cally and have long been known (1) as vaso- pressor drugs, their sites and modes of action appear to vary.The observations presented here throw light upon the circulatory mechanisms in- volved in the pressor response.The subjects were male convalescent patients on the Third (New York University) Medical Division of Bellevue Hospital, who were ex- amined, for the most part, under basal conditions.Adrenin was administered subcutaneously and intramuscularly in 0.5 to 1.5 mgm.doses, ephe- drine was given intramuscularly in 50 to 75 mgm.doses, and paredrinol was injected intramuscularly in 20 to 30 mgm. doses, after control values had been obtained.Cardiac output was determined by a modifica- tion of Starr's ballistocardiograph (2), using the wave area formula advocated by Starr (3).The instrument was calibrated after each study by the method recommended by Starr (4).All figures for stroke volume and cardiac output have been increased by 18.5 per cent because Cournand et al. (2) have shown the ballistocardiographic out-