Key result
Epinephrine markedly potentiates thrombin-induced aggregation and dense granule secretion in human platelets.
Epinephrine and thrombin exhibit synergistic effects on human platelet aggregation and dense granule secretion, suggesting distinct thresholds of intracellular messengers for these responses.
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Hypothesis-generating for platelet signaling thresholds; leaves open in vivo relevance and should not change practice.
Steen et al. (1985) studied this question. Epinephrine and Thrombin vs. Thrombin alone or Epinephrine alone was evaluated on Aggregation and dense granule secretion. Epinephrine (0.5-4 microM) markedly potentiated thrombin-induced (0.03-0.3 U/ml) aggregation and dense granule secretion in human platelets, lowering the threshold for half-maximal response.
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