Biomedical behavior of some amino‐containing polymers in contact with blood constituents

The present paper is concerned with studies for elucidation of the relationship between the structure of HA copolymers and their adsorption property toward lymphocyte subpopulations, B cell and T cell. HA is a polyamine graft copolymer of poly(hydroxyethyl methacrylate) as the backbone. In the earlier part of this paper, discussion will be made on our synthetic approach to HA copolymers having polyamine graft chains of controlled length and number, while, in the later part, the outline of our recent studies of biomedical behavior of HA copolymers in terms of selective adsorption of B cell against T cell will be presented. A possible mechanism for the cell separation will also be discussed.