Key result
Moving the arterial stenosis location closer to the microcirculation zone resulted in lower blood flow velocity, pressure, and wall shear stress in a numerical simulation model.
Why the study?
Arterial stenosis threatens life and health, prompting this investigation into changes in hemodynamic parameters across different arterial stenosis locations.
Computational modeling demonstrates that arterial stenosis location significantly impacts hemodynamics, highlighting the importance of incorporating microcirculation in numerical simulations.
Stenosis location may alter modeled hemodynamics; leaves open whether microcirculation-inclusive simulations improve human coronary assessment.
BACKGROUND: In recent years, arterial stenosis has become one of the serious diseases threatening people's life and health. OBJECTIVE: The main purpose of the present study is to examine the changes of hemodynamic parameters in different stenosis locations of arteries. METHODS: An arterial stenosis model with fluid-structure interaction and microcirculation as the outlet boundary of seepage is adopted in this paper. Considering the interaction between blood and arterial wall, a numerical simulation is carried out using the finite element method. RESULTS: The results show that hemodynamic parameters are sensitive to the change of stenosis location. The closer to the microcirculation zone the stenosis location, the lower the blood flow velocity, pressure and the wall shear stress. In addition, the velocity trend is transformed from the gradual increase to decrease with the increasing distance away from the inlet when the stenosis location moves to the microcirculation zone. CONCLUSION: This work proves that the stenosis location has a great influence on hemodynamics based on microcirculation function. Microcirculation is an important factor that cannot be ignored in the numerical simulation of arterial hemodynamics. The numerical results could provide the potential of clinical preconditions for disease diagnosis and treatment.
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He et al. (2022) studied Arterial stenosis. Different stenosis locations was evaluated on Hemodynamic parameters (blood flow velocity, pressure, and wall shear stress). Moving the arterial stenosis location closer to the microcirculation zone resulted in lower blood flow velocity, pressure, and wall shear stress in a numerical simulation model.
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