CALR mutation burden in essential thrombocythemia and disease outcome

Paola Guglielmelli; Natasha Szuber; Naseema Gangat; Giulio Capecchi; Chiara Maccari; Michaël Harnois; Omer Karrar; Maymona Abdelmagid; Manjola Balliu; Elena Nacca; Alessandro Atanasio; Ilaria Sestini; Audrey Désilets; Giuseppe Gaetano Loscocco; Giada Rotunno; Lambert Busque; Ayalew Tefferi; Alessandro M. Vannucchi

doi:10.1182/blood.2023023428

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Abstract

Among 281 patients with essential thrombocythemia and calreticulin (CALR) mutation, we found a variant allele frequency of ≥60% to be associated with significantly shortened myelofibrosis-free survival, mostly apparent with CALR type-1 and CALR type-indeterminate mutations.

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Guglielmelli et al. (2024) studied this question.

synapsesocial.com/papers/6aa65f6524d99d1b40dd59b9 https://doi.org/10.1182/blood.2023023428

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CALR mutation burden in essential thrombocythemia and disease outcome

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Abstract

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CALR mutation burden in essential thrombocythemia and disease outcome

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Abstract

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