Does cold hypersensitivity increase with age in sickle cell disease?

1Department of Biopharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, USA Comprehensive Sickle Cell Center, University of Illinois Hospital and Health Sciences System, Chicago, IL, USA 2Department of Biopharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, USA Division of Hematology/Oncology, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA Comprehensive Sickle Cell Center, University of Illinois Hospital and Health Sciences System, Chicago, IL, USA Jesse Brown Veterans Administration Medical Center, Chicago, IL, USA 3Department of Biobehavioral Health Science, College of Nursing, University of Illinois at Chicago, Chicago, IL, USA Comprehensive Sickle Cell Center, University of Illinois Hospital and Health Sciences System, Chicago, IL, USA *Tel.: +1 312 355 1429; fax: +1 312 996 0098. E-mail: [email protected]