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S tem cell therapy has undergone a rapid translation from bench research to clinical trials as a promising approach for the regeneration of the injured myocardium.1,2 Magnetic resonance imaging (MRI) plays a pivotal role in the assessment of stem cell therapy efficacy and elucidation of the mechanisms behind therapeutic effects.3 One important aspect of stem cell therapy, however, remains missing: There are currently no noninvasive methods to evaluate the restoration of myocardial tissue microstructure.A study by Sosnovik et al 4 published in this issue of Circulation fills this gap and demonstrates the feasibility of evaluating the integrity and spatial organization of myofibers after cell therapy.
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Naumova et al. (2014) studied this question.
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