Wound healing activity of aqueous extract of Crotalaria verrucosa in Wistar albino rats

Objective: To evaluate the wound healing effect of aqueous extract of Crotalaria verrucosa (C.verrucosa) in rats. Methods: Three wound models including incision, excision and dead space wmooudnedlss, wgrearneu ulasteidon i nti stshuise sdtruyd yw.e Tighhet , pbarreaamkeintegr ss tsretundgitehd a wnde rhe ybdrreoaxkyipnrgo lsintree ncgotnht einnt iinnc idseioadn swpoaucned wmouodnedls., Rpeerscuelntst:a gTew oof dwoosuensd o fc othnetr aecxttiroanc ta wndit hp earniodd w oift heopuitt hdeelixaalmizeatthioans oinne esxhcoiswieodn tsiisgsnuiefi cbauntt iitn cwraesa sheisg hine rm weiatnh hdyodsreo x8y0p0r omlign/ek,g toctoaml pparortienign wciotnht etnhte acnodn tdrroyl . wTehigeh dt eoxf agmraenthualastoinone treated group showed a significant (P<0.001) reduction in the wound breaking strength when compared to control group in incision type of wound model. Coadministration of C. verrucosa with dexamethasone significantly (P<0.001) increased the breaking strength compared to the cdoenxtarmacettiohna swoanse stirgenaiftiecda notnlyl y( Pg<r0o.u01p). iInnc reexacseisdi obny wtwoou dnods ems oodf etle,s tt heex trpaecrtc oenn taalgl eth oef dtahyes wexocuenpdt tthhee ldoewxearm deothsea swonheic hsu epxphriebsisteedd wonoluyn odn c 1o2ntthra, c1t6iothn .d Iaty ssi gonf idfircuagn ttlrye a(Ptm<e0n.0t0 a1n) dre idt uaclesdo rthevee trismede required for epithelialization and reversed the epithelialization delaying effect of dexamethasone (P<0.001). Conclusions: C. verrucosa was found to possess significant wound healing property. cTohnist rwacatsi oenv,i dseknitn bbyr edaekcirneags est rinen tghteh ,p earnidod g oraf neupliathtieolnia ltiizsastuioen d, riny cwreeaisgeh ti nc othnete rnatt.e Hofe nwcoeu nCd.