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January 1, 1989Chemical and Pharmaceutical BulletinOpen Access

A cytotoxic constituent of Lysimachia japonica Thunb. (Primulaceae) and the structure-activity relationships of related compounds.

Munehisa Arisawa Kazunob OHMURA Akio Kobayashi Naokata Morita

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Abstract

A cytotoxic alkylresorcinol was isolated from Lysimachia japonica THUNB. (Primulaceae) and identified as grevillol (2). It was tested for cytotoxicity against KB, B-16, PC-13, L-5178Y, P-388, and HEp-2 cells in vitro. Synthetic related compounds were also tested for cytotoxicity against the KB cell line, and the structure-activity relationships are discussed.

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Arisawa et al. (1989) studied this question.

synapsesocial.com/papers/6aa668a8bc2c7db7488e6020 https://doi.org/10.1248/cpb.37.2431

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