SummaryThree rabbits with an hereditary defect of the classical third component of complement (absence of C′6) were intravenously injected with 3 × 109 heat-killed S. typhi 0 901 labeled with I131. The rates of blood clearance by the RES in these animals were found to be identical with the rates observed in normal rabbits. Ten minutes after the intravenous injection, 84% of the bacteria were found localized in the liver. It is concluded that the activity of C′6 is without influence on the removal of S. typhi from the blood stream by the RES. The nonparticipation of C′6 in the clearance mechanism distinguishes this reaction from the immune bactericidal action of rabbit serum against 5. typhi 0 901.
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Rother et al. (1965) studied this question.