The application of the Vierordt's method and derivative spectrophotometry for simultaneous determination of amitryptyline (AMT) and chlorpromazine (CPM) hydrochlorides in their binary mixtures are presented. Both methods allow to determine the components without their isolation. By derivative spectrophotometry, amitryptyline hydrochloride can be determined in the range of 2–15 μg/ml and chlorpromazine hydrochloride between 2–53 μg/ml. The acceptable error was obtained when the ratio analyte:second component ranges from 3:1 to 50:1 for amitryptyline and 0.1 : 1–0.8 : 1 for chlorpromazine. The Vierordt's method can be applied for resolution of the studied mixture when the ratio analyte : second component is in the 3:1–45:1 and 11:1–57:1 range for amitryptyline and chlorpromazine, respectively.
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Karpińska et al. (2001) studied this question.
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