A flow-injection method is proposed for the determination of chlorpromazine and other N-substituted phenothiazines. The procedure is based on the oxidation of analyte with lead dioxide entrapped into polymeric material in a packed-bed reactor. The oxidation of the drug yields soluble Pb2-, which is monitored by means of the lead ion selective electrode in the wall-jet configuration. The calibration graph is linear over the range of 0.01 – 2 μg ml−1 of chlorpromazine with relative standard deviation of 1.4% and sample throughput 20 h−1. The developed method was applied to the determination of chlorpromazine in pharmaceutical preparations.
No takes yet. Share an insight, caveat, or question.
Anatol Kojło (1997) studied this question.
Synapse has enriched 5 related papers. Consider them for comparative context: