Direct delivery: Multifunctionalized magnetic nanoparticles, which are highly stable and positively charged, induce strong interactions with cells and nuclei, thus confining bleomycin (BLM) close to its DNA target (see picture; PEG=polyethylene glycol). Grafted BLM can induce significant damage in DNA and cancerous cells.
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Georgelin et al. (2010) studied this question.
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