Key result
A comprehensive network map of the urotensin-II/UTR signaling pathway comprising 190 molecular events was consolidated and made freely accessible through the WikiPathways Database.
Why the study?
Due to the biomedical importance and therapeutic potential of urotensin-II signaling across physiological and pathological conditions, a consolidated network map was needed.
A comprehensive network map of the urotensin-II/UTR signaling pathway was consolidated and made publicly available to facilitate the identification of novel therapeutic targets.
May support urotensin-II target discovery; leaves open clinical translation pending validation.
Urotensin-II is a polypeptide ligand with neurohormone-like activity. It mediates downstream signaling pathways through G-protein-coupled receptor 14 (GPR14) also known as urotensin receptor (UTR). Urotensin-II is the most potent endogenous vasoconstrictor in mammals, promoting cardiovascular remodelling, cardiac fibrosis, and cardiomyocyte hypertrophy. It is also involved in other physiological and pathological activities, including neurosecretory effects, insulin resistance, atherosclerosis, kidney disease, and carcinogenic effects. Moreover, it is a notable player in the process of inflammatory injury, which leads to the development of inflammatory diseases. Urotensin-II/UTR expression stimulates the accumulation of monocytes and macrophages, which promote the adhesion molecules expression, chemokines activation and release of inflammatory cytokines at inflammatory injury sites. Therefore, urotensin-II turns out to be an important therapeutic target for the treatment options and management of associated diseases. The main downstream signaling pathways mediated through this urotensin-II /UTR system are RhoA/ROCK, MAPKs and PI3K/AKT. Due to the importance of urotensin-II systems in biomedicine, we consolidated a network map of urotensin-II /UTR signaling. The described signaling map comprises 33 activation/inhibition events, 31 catalysis events, 15 molecular associations, 40 gene regulation events, 60 types of protein expression, and 11 protein translocation events. The urotensin-II signaling pathway map is made freely accessible through the WikiPathways Database ( https://www.wikipathways.org/index.php/Pathway:WP5158 ). The availability of comprehensive urotensin-II signaling in the public resource will help understand the regulation and function of this pathway in normal and pathological conditions. We believe this resource will provide a platform to the scientific community in facilitating the identification of novel therapeutic drug targets for diseases associated with urotensin-II signaling.
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Balaya et al. (2022) conducted a review in Urotensin-II mediated signaling pathway. Urotensin-II/UTR signaling network map was evaluated on Consolidation of a network map of urotensin-II/UTR signaling. A comprehensive network map of the urotensin-II/UTR signaling pathway comprising 190 molecular events was consolidated and made freely accessible through the WikiPathways Database.
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