Key result
Lower serum and vitreous omentin-1 levels correlate with diabetic retinopathy presence and severity.
Why the study?
Are serum and vitreous concentrations of omentin-1 associated with the presence and severity of diabetic retinopathy?
Observational (n=269)
Are serum and vitreous concentrations of omentin-1 associated with the presence and severity of diabetic retinopathy?
Serum and vitreous omentin-1 levels are inversely correlated with the presence and severity of diabetic retinopathy, suggesting a potential role as a biomarker.
Lower omentin-1 in PDR may mark inflammation; hypothesis-generating for biomarker or mechanistic roles pending prospective studies.
OBJECTIVE: Omentin, a new discovered adipokine, is implicated to inhibit inflammation. Inflammation is one important mechanism of diabetic retinopathy (DR). The purpose of this work was to evaluate serum and vitreous concentrations of omentin-1 in patients with diabetic retinopathy (DR). METHODS: This study enrolled 204 diabetic patients (60 without DR, 49 with NPDR, and 95 with PDR) and 65 control subjects. RESULTS: Serum and vitreous omentin-1 levels in PDR patients were markedly decreased compared with those in the other three groups. NPDR patients showed reduced vitreous omentin-1 compared with patients without DR. In addition, control subjects had significantly higher levels of serum and vitreous omentin-1 compared with diabetic patients without DR, NPDR patients, and PDR patients. In addition, serum/vitreous omentin-1 ratio was positively correlated with the development and severity of DR. CONCLUSION: Serum and vitreous omentin-1 levels, as well as serum/vitreous omentin-1 ratio, are correlated with the presence and severity of DR.
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Wan et al. (2015) conducted an observational in Diabetic retinopathy (n=269). Serum and vitreous omentin-1 levels vs. Control subjects and diabetic patients without retinopathy was evaluated on Presence and severity of diabetic retinopathy. Serum and vitreous omentin-1 levels were significantly lower in patients with diabetic retinopathy compared to controls, and correlated with disease severity.
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