A novel pH-sensitive chiral amphiphile, N -(4-decyloxy-2- hydroxybenzylidene)- l -leucine, was synthesized. Two kinds of vesicles were found at different pH ranges, 6.5−8.0 and 11.5−12.5, and a helical structure was observed at pH = 11.0. This unique behavior can be attributed to the formation of a dimeric structure. The interaction between this amphiphile and β-cyclodextrin was investigated by fluorescence emission spectra, 1 H NMR, and molecular modeling.
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Wang et al. (2003) studied this question.
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