Key result
Lower serum and follicular fluid EMMPRIN levels linked to successful pregnancy.
Why the study?
EMMPRIN plays an important role in embryo implantation, but its relationship with pregnancy rates in intracytoplasmic sperm injection patients required evaluation.
Do EMMPRIN levels in serum and follicular fluid predict pregnancy rates in infertile women undergoing ICSI?
Cross-Sectional (n=58)
Do EMMPRIN levels in serum and follicular fluid predict pregnancy rates in infertile women undergoing ICSI?
Lower EMMPRIN levels in serum and follicular fluid during ICSI cycles are associated with higher pregnancy rates, suggesting its potential as a predictive biomarker.
Lower EMMPRIN levels were associated with pregnancy after ICSI; leaves open its value as predictor pending prospective validation.
EMMPRIN (Basigin) is a potent inducer of matrix metalloproteinases (MMPs). Expression of EMMPRIN in the uterus has a very important role in implantation of embryo, this study was conducted to evaluate the relationship of pregnancy rates with EMMPRIN levels in follicular fluid and serum of intracytoplasmic sperm injection patients. The study was cross sectional study analyzed the serum and follicular fluid samples of 58 patients undergo ICSI procedure. The serum and follicular fluid samples were collected from infertile women aged 20 to 42 years. However, the levels of EMMPRIN were measured in the serum and follicular fluid samples and these samples were obtained during oocytes retrieval and another serum samples were collected at the day of embryo transfer. All women have ovarian stimulation with recombinant follicle stimulating hormone (FSH) at the second or third day of the cycle. Result: The pregnancy rate was 27.6 %. The present study showed that EMMPRIN in serum and follicular fluid at day of ova pickup and its level at embryo transfer day, are significantly low in pregnant women (p < 0.05) compared to non-pregnant women. The statistical analysis showed no significant correlation between serum and follicular fluid EMMPRIN with endometrial thickness (p > 0.05). EMMPRIN level can be used as a promising parameter for the prediction of pregnancy rate in ICSI cycles
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Almousa et al. (2022) conducted a cross-sectional in Infertility (n=58). EMMPRIN levels in serum and follicular fluid was evaluated on Pregnancy (p=<0.05). Serum and follicular fluid EMMPRIN levels at the day of ova pickup and embryo transfer were significantly lower in pregnant women compared to non-pregnant women (p < 0.05).
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