Hepatitis Associated with Dantrolene Sodium

Letters1 January 1976Hepatitis Associated with Dantrolene SodiumROBERT M. OGBURN, M.D., ROBERT L. MYERS, M.D., GEORGE E. BURDICK, M.D.ROBERT M. OGBURN, M.D.Search for more papers by this author, ROBERT L. MYERS, M.D.Search for more papers by this author, GEORGE E. BURDICK, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-84-1-53 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDantrolene sodium, a hydantoin derivative that became commercially available in 1974, has been used to decrease skeletal muscle spasticity in patients with various disorders (1-3). The drug seems to exert its effect at a point distal to the neuromuscular junction by impairing release of calcium from the sarcoplasmic reticulum of the skeletal muscle cell (4). Reported adverse effects of dantrolene have included central nervous system effects (drowsiness, dizziness, weakness, light-headedness) and transient gastrointestinal upset with nausea, vomiting, or diarrhea. Adverse reactions have necessitated withdrawal of the drug in about 2.5% of cases (4).Acute hepatitis associated with the administration of...References1. MAYERMECOMBERHERMAN NSR: Treatment of spasticity with dantrolene sodium. Am J Phys Med 52:18-29, 1973 MedlineGoogle Scholar2. GELENBERGPOSKANZER AD: The effect of dantrolene sodium on spasticity in multiple sclerosis. Neurology 23:1313-1315, 1973 CrossrefMedlineGoogle Scholar3. CHYATTEBASMAJIAN SJ: Dantrolene sodium: long-term effects in severe spasticity. Arch Phys Med Rehabil 54:311-315, 1973 MedlineGoogle Scholar4. DYKES H: Evaluation of a muscle relaxant: dantrolene sodium (Dantrium). JAMA 231:862-864, 1975 CrossrefMedlineGoogle Scholar5. DHARPIERACHAHAMED GCP: Diphenylhydantoin-induced hepatic necrosis. Postgrad Med 56:128-134, 1974 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Gastroenterology Service Letterman Army Medical Center Presidio of San Francisco, California 94129 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByIdentification of enzymes responsible for dantrolene metabolism in the human liver: A clue to uncover the cause of liver injuryHeat StrokeAdverse Effects of Drugs on the LiverOral Dantrolene Sodium for Tonsillectomy Pain: A Double-Blind StudyHepatotoxicological Evaluation of Dantrolene SodiumDrug effects on the liverDrugs and Liver Disease: A Tabular Compilation of Drugs and the Histopathological Changes That Can Occur in the LiverThe effect of dantrolene sodium in relation to blood levels in spastic patients after prolonged administration.Drug effects on the liverMassive hepatic necrosis associated with dantrolene therapyDantrolene-Associated HepatitisDantrolene-Associated Hepatic InjuryMuscle relaxants 1 January 1976Volume 84, Issue 1Page: 53-54KeywordsAdverse reactionsDiarrheaDrugsHepatitisHepatitis AMuscle cellsNauseaSkeletal musclesSodiumVomiting Issue Published: 1 January 1976 PDF DownloadLoading ...