Key result
Propranolol reduces isoprenaline-induced dP/dt max for a given heart rate in dogs.
Why the study?
Does intravenous propranolol alter the relationship between heart rate and left ventricular dP/dt max induced by isoprenaline in dogs?
Population
Dogs (including a subset previously depleted of catecholamines by treatment with reserpine)
Comparison
Propranolol (intravenous, dose up to 1-2 mg/kg) vs Absence of propranolol
Design
Preclinical
Authors
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No direct implications for human beta-blocker dosing; leaves open translation of canine dP/dt max findings to clinical LV function.
Does intravenous propranolol alter the relationship between heart rate and left ventricular dP/dt max induced by isoprenaline in dogs?
Intravenous propranolol acts as a pure beta-adrenoreceptor blocking drug at doses up to 1-2 mg/kg in dogs, reducing left ventricular dP/dt max without affecting baseline heart rate.
Harry et al. (1973) studied this question. Propranolol vs. Absence of propranolol was evaluated on Relationship between free heart rate and dP/dt max in the left ventricle induced by isoprenaline. Propranolol reduced dP/dt max for a given free heart rate induced by isoprenaline in dogs, acting as a pure beta-adrenoreceptor blocking drug at intravenous doses up to 1-2 mg/kg.