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Sickle cell disease (SCD) affects 100 000 Americans, mostly belonging to racially minoritized, underserved populations. 1 Because of the increasing use of disease-modifying therapies, such as hydroxyurea, individuals with SCD are surviving into adulthood with less morbidity.1,2 Long-term effects of SCD and its treatments are coming into focus, such as potential impacts on fertility and reproductive health.2,3 Recent recommendations are to incorporate these topics (eg, fertility, contraception, sexual health, genetic counseling, pregnancy-related care) into routine, comprehensive care for SCD. 3 In this commentary, we will review recent evidence regarding fertility concerns and research gaps in boys and men with SCD, specifically focusing on clinical and ethical challenges salient to adolescents.
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Nahata et al. (2023) studied this question.
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