Enamine‐Mediated Azide‐Ketone [3 + 2] Cycloaddition of Azidoperfluoroalkanes

An effective synthesis of highly functionalized N ‐perfluoroalkyl‐1,2,3‐triazoles from azidoperfluoroalkanes has been achieved. In situ generated enamines readily participate in the azide‐carbonyl [3+2] cycloaddition, providing a facile way to fully substituted triazole frameworks in good to excellent yields. The synthetic value of these triazoles was shown in the synthesis of perfluorinated 1,5‐disubstituted triazoles by hydrolysis and decarboxylation.