Key result
Glutaraldehyde-tanned autogenous pericardial chordae retain central pliability and avoid uniform fibrosis versus untreated tissue.
Supports preclinical development of tanned pericardial chordae; leaves open translation to human valve surgery.
Glutaraldehyde-tanned autogenous pericardium was compared with untreated autogenous pericardium as a tissue for replacement of anterior chordae tendinae of the mitral valve. Tanned autogenous pericardial chordae have a marked fibrous reaction at their healing ends but retain central pliability. Untreated autogenous pericardial chordae become uniformly fibrosed and stiff. Both retain their length, heal well to the papillary muscle and cusp, and are considered as potentially useful chordal substitutes in the right circumstances. Some of the response of the host to implanted tanned xenograft tissue must be related to the consequences of tanning rather than a reaction to foreign tissue.
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Bortolotti et al. (1984) studied Mitral valve chordae replacement. Glutaraldehyde-tanned autogenous pericardium vs. Untreated autogenous pericardium was evaluated on Tissue healing and pliability. Glutaraldehyde-tanned autogenous pericardial chordae retained central pliability compared to untreated chordae which became uniformly fibrosed and stiff, though both healed well.
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