Key result
Female gender linked to ~47% greater risk of depressive disorders in hepatocellular carcinoma patients.
Why the study?
What are the risk factors for developing depressive disorders in patients with Hepatocellular Carcinoma?
Cohort (n=55,973)
What are the risk factors for developing depressive disorders in patients with Hepatocellular Carcinoma?
Patients with hepatocellular carcinoma are at risk of developing depressive disorders, particularly those who are female, aged 40-79, have metastasis, or have HCV.
BACKGROUND & AIMS: To evaluate the risk of depressive disorders among patients with Hepatocellular Carcinoma (HCC) using the National Health Insurance Research Database (NHIRD) in Taiwan. METHODS: We conducted a retrospective study of a newly diagnosed HCC cohort of 55,973 participants who were selected from the NHIRD. Patients were observed for a maximum of 6 years to determine the rates of newly onset depressive disorders, and Cox regression was used to identify the risk factors associated with depressive disorders in HCC patients. RESULTS: Of the total 55,973 HCC patients, 1,041 patients (1.86%) were diagnosed with depressive disorders during a mean (SD) follow-up period of 1.1 (1.2) years. The Cox multivariate proportional hazards analysis showed that age of 40-59 (HR 1.376, 95% CI 1.049-1.805, p = 0.021), age of 60-79 (HR 1.341, 95% CI 1.025-1.753, p = 0.032), women (HR 1.474 95% CI 1.301-1.669, p < 0.001), metastasis (HR 1.916, 95% CI 1.243-2.953, p = 0.003), and HCV (HR 1.445, 95% CI 1.231-1.697, p < 0.001) were independent risk factors for developing depressive disorders. CONCLUSIONS: Our study indicated a subsequent risk of depressive disorders in patients with HCC, and the risk increased for those with female gender, aged 40 to 59, aged 60 to 79, with metastasis, or with HCV. Psychological evaluation and support are two critical issues in these HCC patients with the risk factors.
No takes yet. Share an insight, caveat, or question.
Chang et al. (2015) conducted a cohort in Hepatocellular Carcinoma (HCC) (n=55,973). Female gender vs. Male gender was evaluated on Incidence of newly onset depressive disorders (HR 1.474, 95% CI 1.301-1.669, p=<0.001). Among patients with hepatocellular carcinoma, female gender significantly increased the risk of developing depressive disorders compared to male gender (HR 1.474), alongside other independent risk factors including age 40-79, metastasis, and HCV infection.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: