Antisera prepared by giving New Zealand white rabbits injections of perchloric acid extracts of 12-week human fetuses demonstrated the presence of fetal antigenic components on the surface of human malignant melanoma cells and the cells of other human tumors. The antifetal serum reacted only with the surface of tumor cells and fetal cells, not with a number of normal adult cells. The relationship with carcinoembryonic antigen and other fetal antigens is briefly discussed. The antifetal serum did not block or was not blocked by tumor-specific surface membrane reactions in the same individuals.
No takes yet. Share an insight, caveat, or question.
Avis et al. (1973) studied this question.