Key result
Tropical myositis muscle biopsies show patchy myocytolysis and reveal virus-like intracellular vesicles in ~22% of patients.
Observational (n=9)
Ultrastructural studies of tropical myositis lesions suggest a potential viral etiology based on the presence of virus-like vesicles.
Suggests possible viral etiology in tropical myositis; hypothesis-generating and should not change practice.
Specimens of muscle were obtained from non-suppurating lesions of nine patients with tropical myositis. When examined in an electron microscope, these revealed patchy myocytolysis with loss of band structure. Perimysial cells were also degenerate. Sections from two out of nine patients revealed intracellular vesicles, about 80 nm in diameter, some of which contained 10 nm granules. These vesicles were seen budding from cell membranes and resembled virus particles. The focal necrosis with which they are associated and their absence from control sections support the concept that they are related to the disease process.
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Taylor et al. (1976) conducted an observational in Tropical myositis (n=9). Tropical myositis vs. Control sections was evaluated on Ultrastructural changes (patchy myocytolysis, intracellular vesicles). Electron microscopy of muscle from patients with tropical myositis revealed patchy myocytolysis and, in 2 of 9 patients, virus-like intracellular vesicles that were absent in control sections.
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