Recent studies on bacterial population changes, involving the selective establishment of mutants differing not only in colonial morphology, antigenic characteristics and virulence but also in resistance to specific extracellular metabolites (amino acids) produced by the parent cells, have been reviewed. Certain parallels between these phenomena and such problems as antigenic transformation in Paramecium, developmental differentiation, and neoplastic growth have been discussed.
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Werner Braun (1952) studied this question.
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