Resistance is futile: Pathogenic bacteria that produce metallo-β-lactamases are recognized as a serious threat because of their resistance to antibiotics. The title compound has now been shown to be an irreversible inhibitor for a metallo-β-lactamase (IMP-1). The X-ray crystallographic structure (see picture) has revealed that the inhibitor binds to IMP-1 with formation of a covalent amide bond with the amino group (Nζ) of Lys 224.
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Kurosaki et al. (2005) studied this question.
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