Key result
Complete excision of an auricular nodule in angiolymphoid hyperplasia maintains tumor-free status at ~13 months.
Case Report (n=1)
This case report highlights the potential role of sex hormones in the pathogenesis of angiolymphoid hyperplasia with eosinophilia during pregnancy, which was successfully treated with surgical excision.
Surgical excision may control auricular ALHE in pregnancy; single case leaves open hormonal pathogenesis and broader applicability.
A case of angiolymphoid hyperplasia with eosinophilia (ALH) is reported in a 33-year-old woman who developed an auricular nodule during the second trimester of her pregnancy. Angiolymphoid hyperplasia with eosinophilia usually occurs on the head and neck of young adults and is more common in women than in men. Characteristic histologic features of ALH present in this case included proliferation of thick-walled blood vessels lined by prominent endothelial cells, infiltration of the interstitium by chronic inflammatory cells (mainly eosinophils), and presence of lymphoid follicles with germinal centers. The auricular tumor was completely excised. Thirteen months after excision, the patient remains tumor free. Although there are not many case reports on ALH during pregnancy or involving use of oral contraceptive pills, sex hormones may play a role in the pathogenesis of ALH. This hypothesis, in the context of cases previously described in the literature, and the differential diagnosis of ALH are discussed.
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Zarrin‐Khameh et al. (2005) conducted a case report in Angiolymphoid hyperplasia with eosinophilia (n=1). Complete excision was evaluated on Tumor recurrence. Complete excision of an auricular nodule in a 33-year-old pregnant woman with angiolymphoid hyperplasia with eosinophilia resulted in the patient remaining tumor-free at 13 months follow-up.
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