Key result
Wide resection successfully treats rare mandibular intraosseous epithelioid hemangioendothelioma in a 76-year-old woman.
Case Report (n=1)
Intraosseous epithelioid hemangioendothelioma of the mandible is a rare tumor with borderline malignant potential that can be successfully treated with wide resection.
Supports wide resection for rare mandibular intraosseous epithelioid hemangioendothelioma; hypothesis-generating and should not yet change practice.
Epithelioid hemangioma is the prototype of a group of vascular tumors characterized by epithelioid endothelial cells. Hemangioendothelioma of bone is a rare lesion that constitutes less than 0.5% of primary malignant skeletal tumors. We report and discuss a case of epithelioid hemangioendothelioma arising intraosseously in the anterior portion of the mandible in a 76-year-old woman. The case was treated successfully by wide resection. Radiographically, the tumor mass showed osteolysis and expansion. Histologically, the tumor showed invasive and destructive growth, although it lacked frequent mitotic figures and severe atypia. On immunohistochemical study, tumor cells exhibited characteristics of mesenchymal and endothelial origin, i.e., strong to moderate immune reactivity against vimentin, factor VIII-related antigen (F8RA), Ulex europaeus agglutinin type 1 lectin (UEA-1), and CD 34, but not against keratin, epithelial membrane antigen (EMA) or S-100 protein (S100). The proliferating cell nuclear antigen (PCNA)-positive cell index was 27.5%. These pathological findings suggested a borderline malignant potential for this tumor. Thus, clinically, wide resection with or without dissection of regional lymph nodes is recommended.
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Hamakawa et al. (1999) conducted a case report in Intraosseous epithelioid hemangioendothelioma of the mandible (n=1). Wide resection was evaluated. Wide resection successfully treated a 76-year-old woman with intraosseous epithelioid hemangioendothelioma of the mandible, a rare tumor with borderline malignant potential.