IT IS generally believed that estrogens are rapidly inactivated by the liver, this belief being based largely upon data obtained from four types of observation, a) Liver tissue (dog, rat, mouse, rabbit, guinea-pig, frog) and cell-free extracts of liver have been found to inactivate estrogens in vitro (Silberstein, et al., 1933; Zondek, 1934; Engel and Navratel, 1937; Heller, et al, 1939; Heller, 1940; Engel, 1941; Heller and Heller, 1943). b) It was reported (Israel, et al., 1937) that estrone s i not inactivated when perfused through a heart-lung preparation (dog) but is rapidly (within 15 minutes) inactivated when perfused through a heart-lung-liver preparation, c) Ovaries transplanted to the mesentery (Golden and Sevringhaus, 1942) or pellets of crystalline estrogen implanted in the spleen (Biskind and Mark, 1939; Biskind, 1940, 1941) exert little or no estrogenic effect as comparedwith their characteristic action when implanted subcutaneously.
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Cantarow et al. (1943) studied this question.