Poly(d,l-lactide-co-glycolide), PLGA, is a biodegradable polyester with many medical applications. In this article, several catalysts are studied as potential substitutes of the conventional catalyst, tin (II) 2-ethylhexanoate (known as tin octoate, SnOct2). Namely, different metal carboxylates have been examined, in order to study the influence of the metal counterion. Among them, most promising results have been obtained when using zinc (II) 2-ethylhexanoate (ZnOct2) followed by potassium (I) 2-ethylhexanoate. Furthermore, in the case of ZnOct2, the use of alcohols as initiators was examined in order to improve reaction rate and to study their effect on molecular weight distribution, polymer microstructure, and side reactions, such as transesterification reaction.
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Mazarro et al. (2009) studied this question.
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