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Cryptic epitopes alter the immune responseIn this issue of the JCI, Dutoit and collaborators (11) describe the generation of "low-quality" CTL responses in cancer patients vaccinated with two synthetic peptides derived from the sequence of the cancertestis NY-ESO-1 tumor antigen (12).Both of the above-mentioned mechanisms appear to be responsible for this outcome.
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Esteban Celis (2002) studied this question.
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