MicroRNAs in the Occurrence and Development of Primary Hepatocellular Carcinoma

ries of important genes, may play a critical role.The aim of this paper was to summarize the role of microRNAs in the occurrence and development of hepatocellular carcinoma.Meanwhile, we depicted microRNAs as a biomarker for early diagnosis and treatment of hepatocellular carcinoma. Hepatocellular CarcinomaHepatocellular carcinoma is one of the most common cancers in the world.It is the second leading cause of cancer-related death of men and sixth leading cause of cancer-related deaths of women [5].Hepatocellular carcinoma (HCC), of which 70-85% of patients have primary HCC, rarely can be detected in its early stages, so the survival Hepatocellular carcinoma (HCC) is the fifth most common malignant cancer and the second most common cause of cancer-related deaths in the world [1].Population-based studies show that the incidence rate continues to approximate the death rate, indicating that most of the patients who develop HCC die of it [1].In recent years, the molecular mechanisms for the development of hepatocellular carcinoma have made tremendous progress.It has been reported that the abnormal expression of cell cycle regulatory proteins such as P53, c-Myc, CyclinD1 and the genes involved in the Wnt/-catenin signaling pathway and a variety of tyrosine kinase growth factor receptors and ligands play a significant role in the pathogenesis of hepatocellular carcinoma [3,4].