Modulation of in Vitro Release of Crystal Violet From a Binary Polymer Hydrogel System

A macromolecular vehicle entrapping crystal violet (CV) as a model drug was developed by crosslink polymerization of acrylamide and styrene in the presence of a hydrophilic polymer poly(vinyl alcohol). The loaded polymer matrix was monitored for the controlled release of the crystal violet by a spectrophotometric method. The dynamics of the release process was investigated as a function of the composition of the gel and pH of the release medium. The mechanism of the release process was examined kinetically in terms of the quantitative parameters such as the diffusional exponent n and diffusion constant D evaluated using the Ficks equations.