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The diphenol 1 was resolved into its antipodes and their absolute configuration was established. The levorotatory isomer R‐(−)‐1 was oxidized to the dienone R‐(−)‐6, which was rearranged to afford natural (−)‐multifloramine (R‐(−)‐7), thus establishing that the latter has the R‐configuration. By the same reaction sequences, the enantiomeric diphenol S‐(+)‐1 was transformed to provide (+)‐multifloramine (S‐(+)‐7) of the S‐configuration.
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BROSSI et al. (1969) studied this question.
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