Key result
Direct hemoadsorption therapy using the Rheocarna device resulted in the healing of multiple toe ulcers and improvement of mottled cyanosis in a patient with refractory blue toe syndrome.
Why the study?
Blue toe syndrome is often refractory with no established treatment.
Does direct blood adsorption therapy with the Rheocarna device improve ulcer healing in a patient with refractory blue toe syndrome?
Case Report (n=1)
Does direct blood adsorption therapy with the Rheocarna device improve ulcer healing in a patient with refractory blue toe syndrome?
Direct hemoadsorption therapy with the Rheocarna device may be a promising treatment for refractory blue toe syndrome.
May support Rheocarna hemoadsorption in refractory blue toe syndrome; leaves open confirmation in prospective trials.
A man in his 80s who was on maintenance dialysis and warfarin therapy for atrial fibrillation developed sudden mottled cyanosis and multiple ulcers on his toes, without any apparent trigger. Despite no significant stenosis in the lower extremity arteries, he had a shaggy mural thrombus in the abdominal aorta, leading to a diagnosis of blue toe syndrome. Conservative treatment was ineffective, prompting the use of a novel apheresis device (Rheocarna®; Kaneka Corporation, Osaka, Japan) for direct blood adsorption therapy. This intervention resulted in the healing of his toe ulcers. Blue toe syndrome is often refractory with no established treatment. The Rheocarna® device shows promise as a potential therapeutic agent.
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Nishiyama et al. (2025) conducted a case report in Blue toe syndrome (n=1). Rheocarna device (direct hemoadsorption therapy) was evaluated on Healing of toe ulcers and improvement of cyanosis. Direct hemoadsorption therapy using the Rheocarna device resulted in the healing of multiple toe ulcers and improvement of mottled cyanosis in a patient with refractory blue toe syndrome.
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