High heterogeneity and low reliability in the diagnosis of major depression will impair the development of new drugs

Samuel Lieblich; David Castle; Christos Pantelis; Malcolm Hopwood; Allan H. Young; Ian Everall

doi:10.1192/bjpo.bp.115.000786

October 1, 2015BJPsych OpenOpen Access

High heterogeneity and low reliability in the diagnosis of major depression will impair the development of new drugs

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Abstract

SUMMARY: Major depressive disorder is a common diagnosis associated with a high burden of disease that has proven to be highly heterogeneous and unreliable. Treatments currently available demonstrate limited efficacy and effectiveness. New drug development is urgently required but is likely to be hindered by diagnostic limitations. DECLARATIONS OF INTEREST: D.

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Lieblich et al. (2015) studied this question.

synapsesocial.com/papers/6aa6d6f93f91f0dc52791d5e https://doi.org/10.1192/bjpo.bp.115.000786

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High heterogeneity and low reliability in the diagnosis of major depression will impair the development of new drugs

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High heterogeneity and low reliability in the diagnosis of major depression will impair the development of new drugs

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