Key result
Duchenne muscular dystrophy links to higher knee extensor SEC stiffness index correlating with disease involvement.
Why the study?
Is the series elastic component stiffness index of knee extensors altered in boys with Duchenne muscular dystrophy compared to controls?
Observational
Is the series elastic component stiffness index of knee extensors altered in boys with Duchenne muscular dystrophy compared to controls?
The SEC stiffness index of knee extensors is elevated in boys with Duchenne muscular dystrophy and correlates with disease involvement, suggesting its potential utility in monitoring disease progression.
May support noninvasive DMD progression monitoring; hypothesis-generating and should not yet change practice.
The series elastic component (SEC) of Hill's muscle model is sensitive to a modification in muscle functional demand. In this study, SEC stiffness was quantified from quick-released movements in knee extensors of Duchenne muscular dystrophy (DMD) boys to look for possible modifications with the stage of disease. A SEC stiffness index (SI) was defined and was found significantly lower for controls than for DMD. Moreover, a linear relationship was established between mean SI and knee extensors involvement. This suggests a role for this parameter, together with other functional tests, for following patients with DMD.
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Cornu et al. (1998) conducted an observational in Duchenne Muscular Dystrophy. Duchenne muscular dystrophy vs. Controls was evaluated on Series elastic component (SEC) stiffness index (SI). The series elastic component stiffness index of knee extensors was significantly higher in boys with Duchenne muscular dystrophy compared to controls and correlated with disease involvement.
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