Key result
Among patients with microvascular angina, 40% met criteria for panic disorder and had chest pain following lactate infusion, though psychologic differences remained between the groups.
Why the study?
What are the clinical and psychologic differences between patients with microvascular angina and panic disorder, and how do MVA patients respond to lactate infusion?
Observational (n=30)
What are the clinical and psychologic differences between patients with microvascular angina and panic disorder, and how do MVA patients respond to lactate infusion?
A significant proportion of patients with microvascular angina meet criteria for panic disorder and experience chest pain after lactate infusion, suggesting overlapping pathophysiology or comorbidity.
May indicate panic disorder overlap in microvascular angina; hypothesis-generating for lactate infusion utility and causal links.
Recent cardiac studies have suggested that patients with chest pain and angiographically normal coronaries have "microvascular angina" (MVA). In contrast, prior psychiatric studies have shown that some of these patients have panic disorder (PD). We compared the clinical and psychologic characteristics of fifteen patients with MVA and fifteen patients with panic disorder (PD), and examined response to lactate infusion in a subgroup of MVA patients. Although 40 percent of MVA patients met criteria for PD and had chest pain following lactate infusion, there were psychologic and symptomatic differences between the MVA and PD groups. These results reflect either co-morbidity of MVA and PD in some patients or two types of MVA, one of primary cardiac origin and one a centrally mediated epiphenomenon of the increased autonomic arousal seen in PD.
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Roy‐Byrne et al. (1990) conducted an observational in Microvascular angina and panic disorder (n=30). Microvascular angina vs. Panic disorder was evaluated on Meeting criteria for panic disorder and chest pain following lactate infusion. Among patients with microvascular angina, 40% met criteria for panic disorder and had chest pain following lactate infusion, though psychologic differences remained between the groups.
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