Key result
CO2 angiography offers a safe, feasible alternative to iodinated contrast for RDN in renal insufficiency.
CO2 angiography provides a feasible and safe alternative to iodinated contrast for renal sympathetic denervation in patients with renal impairment.
May enable RDN in renal insufficiency; leaves open need for randomized confirmation.
Objective: Hypertension is the leading attributable cause of cardiovascular mortality worldwide. Patients with hypertension have multiple comorbidities including high rates of concomitant renal disease. Current pharmacological approaches are inadequate in the treatment of resistant hypertension. Renal sympathetic denervation (RDN) has been shown to effectively treat resistant hypertension. The traditional use of iodinated contrast in RDN is contraindicated in patients with significant renal insufficiency. In patients with renal impairment, carbon dioxide (CO2) can be used as an alternative contrast material for RDN. This article describes the technical aspects of RDN using CO2 angiography. Methods: Our centre is experienced in the innovative RDN procedure using CO2 angiography. We describe the protocol for CO2 angiography for RDN using a home-made CO2 delivery system and the Symplicity™ (Minneapolis MN 55432 USA) catheter (Medtronic) device. Results: CO2 angiography is an excellent alternative to iodinated contrast for RDN procedures. Conclusion: CO2 angiography for RDN is a safe and effective alternative to iodinated contrast. RDN using CO2 angiography is an easy and feasible procedure that can be used in patients with renal insufficiency or iodinated contrast allergies. Advances in knowledge: There is a paucity of descriptive reports for CO2 angiography for RDN and we provide details of the optimal protocol for the procedure. In particular, we describe the use of a Symplicity Spyral™ catheter (Medtronic), which has not been reported to date for use in this procedure.
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Renton et al. (2016) studied Resistant hypertension with renal insufficiency. Carbon dioxide (CO2) angiography for renal sympathetic denervation vs. Iodinated contrast was evaluated. Carbon dioxide angiography for renal sympathetic denervation is described as a safe and feasible alternative to iodinated contrast for patients with renal insufficiency.
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