R′ plasmids have been generated that contain a determinant of Shigella dysenteriae 1 which directs the synthesis of Shiga toxin in Escherichia coli K-12. This gene is closely linked to the argE locus and thus is located in a region of the Shigella chromosome known to contain determinants of virulence factors.
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Timmis et al. (1985) studied this question.
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