An Efficient and Facile Synthesis of 1H‐Pyrazolo[1,2‐b]phthalazine‐5,10‐dione Derivatives of Biological Interest

A simple and efficient method has been developed for the synthesis of 1H‐pyrazolo[1,2‐b]phthalazine‐5,10‐dione derivatives through a one‐pot three‐component condensation reaction of 2‐chloro‐3‐formyl quinolines, malononitrile/ethyl cyanoacetate and 2,3‐dihydro‐1,4‐phthalazinedione using a catalytic amount of piperidine in refluxing ethanol. All the synthesized compounds were screened for their antibacterial activity against a panel of pathogenic strains of bacteria and fungi.