Purification of natural products and the fractionation of crude plant extracts are processes which traditionally involve adsorption and/or molecular exclusion chromatography. While countercurrent chromatography avoids the irreversible adsorption and decomposition frequently encountered in adsorption chromatography, the classical countercurrent distribution technique is both time- and solvent-consuming, consequently it is of limited value today. Rotation locular countercurrent chromatography (RLCC) is one of three new countercurrent techniques, the others being droplet contercurrent chromatography (DCCC)1 and planet coil countercurrent chromatography (PCCCC)2, which have revived the chromatographic application of liquid-liquid partition. We have employed a commercially available RLCC apparatus in the isolation of several natural products with a broad range of polarity demonstrating the versatility of the RLCC with regard to the functionality of the compounds to be isolated.
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Snyder et al. (1984) studied this question.
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