Effect of the oil of Thuja dolabrata and its components on pathogenic and nonpathogenic hyphomycetes was tested. Of the several components of this oil, hinokitiol was the most effective, being effective up to 64, 000 to 128, 000 dilutions against Trichophyton, Epidermophyton, and Anchorion, followed by l-rhodinic acid and thujopsol. Non-pathogenic fungi were found to be very resistant and hinokitiol was effective only in 8, 000-16, 000 dilutions. Based on the assumption that the antifungal action of hinokitiol was due to its formation of complex salts, effect of its iron, zinc, and copper salts were tested and it was found that, as in the case of oxine, the addition of iron complex resulted in complete invalidation, while that of zinc complex reduced the effect to one-quarter, and the addition of copper complex failed to bring out any difference. This specificity of the copper complex was assumed to be due to its substitution with the iron complex, as in the case of oxine.
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Okazaki et al. (1954) studied this question.